› 1f16

Solution NMR

SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTEIN BAX

Released:
DOI: 10.2210/pdb1f16/pdb
PDB entry 1f16 coloured by chain, ensemble of 20 models, front view.
PDB entry 1f16 coloured by chain, ensemble of 20 models, side view.
PDB entry 1f16 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of Bax: coregulation of dimer formation and intracellular localization.
Suzuki M, Youle RJ, Tjandra N
Cell 103 645-54 (2000)
PMID: 11106734

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170507 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apoptosis regulator BAX Chain: A
Molecule details ›
Chain: A
Length: 192 amino acids
Theoretical weight: 21.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07812 (Residues: 1-192; Coverage: 100%)
Gene names: BAX, BCL2L4
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DISTANCE GEOMETRY SIMULATED ANNEALING MOLECULAR DYNAMICS
Expression system: Escherichia coli

Quick links

Citations

173 review citations

Cell death: critical control points.
Danial et al. (2004)
172 more

89 mentions without citation

Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis.
Westphal et al. (2014)
88 more