› 1f23

X-ray diffraction
2.3Å resolution

CONTRIBUTION OF A BURIED HYDROGEN BOND TO HIV-1 ENVELOPE GLYCOPROTEIN STRUCTURE AND FUNCTION

Released:
DOI: 10.2210/pdb1f23/pdb
PDB entry 1f23 coloured by chain, front view.
PDB entry 1f23 coloured by chain, side view.
PDB entry 1f23 coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Structural and functional analysis of the HIV gp41 core containing an Ile573 to Thr substitution: implications for membrane fusion.
Liu J, Shu W, Fagan MB, Nunberg JH, Lu M
Biochemistry 40 2797-807 (2001)
PMID: 11258890

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein gp41 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 76 amino acids
Theoretical weight: 8.82 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: Q89797 (Residues: 542-577, 592-657; Coverage: 8%)
Gene name: env
Sequence domains: Retroviral envelope protein
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P1
Unit cell:
a: 38.92Å b: 41.87Å c: 55.98Å
α: 90.59° β: 88.93° γ: 96.28°
R-values:
R R work R free
0.191 0.191 0.27
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Molecular basis of human immunodeficiency virus type 1 drug resistance: overview and recent developments.
Menéndez-Arias L. (2013)
3 more

10 mentions without citation

HIV-1 envelope glycoprotein structure.
Merk et al. (2013)
9 more