› 1f2x

X-ray diffraction
2.1Å resolution

STRUCTURE OF THE SINGLE-DOMAIN CAMELID ANTIBODY CAB-CA05

Released:
DOI: 10.2210/pdb1f2x/pdb
PDB entry 1f2x coloured by chain, front view.
PDB entry 1f2x coloured by chain, side view.
PDB entry 1f2x coloured by chain, top view.
Source organism: Camelus dromedarius
Primary publication:
Canonical antigen-binding loop structures in immunoglobulins: more structures, more canonical classes?
Decanniere K, Muyldermans S, Wyns L
J Mol Biol 300 83-91 (2000)
PMID: 10864500

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-226417 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ANTIBODY HEAVY CHAIN Chains: K, L
Molecule details ›
Chains: K, L
Length: 135 amino acids
Theoretical weight: 14.73 KDa
Source organism: Camelus dromedarius
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21
Unit cell:
a: 29.98Å b: 43.86Å c: 87.95Å
α: 90° β: 93.23° γ: 90°
R-values:
R R work R free
0.19 0.19 0.27
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Nanobodies: natural single-domain antibodies.
Muyldermans S. (2013)
11 more

12 mentions without citation

A single-domain llama antibody potently inhibits the enzymatic activity of botulinum neurotoxin by binding to the non-catalytic alpha-exosite binding region.
Dong et al. (2010)
11 more