› 1f5f

X-ray diffraction
1.7Å resolution

CRYSTAL STRUCTURE OF THE N-TERMINAL G-DOMAIN OF SHBG IN COMPLEX WITH ZINC

Released:
DOI: 10.2210/pdb1f5f/pdb
PDB entry 1f5f coloured by chain, front view.
PDB entry 1f5f coloured by chain, side view.
PDB entry 1f5f coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Steroid-binding specificity of human sex hormone-binding globulin is influenced by occupancy of a zinc-binding site.
Avvakumov GV, Muller YA, Hammond GL
J Biol Chem 275 25920-5 (2000)
PMID: 10859323

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137579 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sex hormone-binding globulin Chain: A
Molecule details ›
Chain: A
Length: 205 amino acids
Theoretical weight: 22.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04278 (Residues: 30-234; Coverage: 55%)
Gene name: SHBG
Sequence domains: Laminin G domain
Structure domains: Jelly Rolls

Ligands and Environments

4 bound ligands:
Ligand CA 1 x CA
Ligand ZN 2 x ZN
Ligand DHT 1 x DHT
Ligand IPA 1 x IPA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF
Spacegroup: R32
Unit cell:
a: 104.02Å b: 104.02Å c: 84.71Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.197 0.197 0.259
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Diverse roles for sex hormone-binding globulin in reproduction.
Hammond GL. (2011)
5 more

6 mentions without citation

Mechanical strength of 17,134 model proteins and cysteine slipknots.
Sikora et al. (2009)
5 more