› 1f5x

Solution NMR

NMR STRUCTURE OF THE Y174 AUTOINHIBITED DBL HOMOLOGY DOMAIN

Released:
DOI: 10.2210/pdb1f5x/pdb
PDB entry 1f5x coloured by chain, ensemble of 20 models, front view.
PDB entry 1f5x coloured by chain, ensemble of 20 models, side view.
PDB entry 1f5x coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation.
Aghazadeh B, Lowry WE, Huang XY, Rosen MK
Cell 102 625-33 (2000)
PMID: 11007481

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151089 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene vav Chain: A
Molecule details ›
Chain: A
Length: 208 amino acids
Theoretical weight: 24.49 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P27870 (Residues: 168-375; Coverage: 25%)
Gene names: Vav, Vav1
Sequence domains: RhoGEF domain
Structure domains: Dbl homology (DH) domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

62 review citations

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors.
Rossman et al. (2005)
61 more

5 mentions without citation

Internal dynamics control activation and activity of the autoinhibited Vav DH domain.
Li et al. (2008)
4 more