Function and Biology Details
Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
Structure domain:
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Histone acetyltransferase KAT2A (preferred)
PDBe Complex ID:
PDB-CPX-187767 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone acetyltransferase KAT2A
Molecule details ›
Chain: A
Length: 103 amino acids
Theoretical weight: 12.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Bromodomain
Structure domains: Bromodomain-like
Length: 103 amino acids
Theoretical weight: 12.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q92830 (Residues: 730-832; Coverage: 12%)
Sequence domains: Bromodomain
Structure domains: Bromodomain-like
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Refinement method:
Torsion angle dynamics (DYANA) for generation of initial structures; Structure-mediated assignment of ambiguous experimental restraints (SANE); Iteration between DYANA and SANE; Simulated Annealing and Energy Minimization in AMBER using full restraint set.
Expression system: Escherichia coli
