› 1f69

X-ray diffraction
2.6Å resolution

CRYSTAL STRUCTURE OF THE B-DNA HEXAMER GGCGCC WITH COBALT HEXAMINE

Released:
DOI: 10.2210/pdb1f69/pdb
PDB entry 1f69 coloured by chain, front view.
PDB entry 1f69 coloured by chain, side view.
PDB entry 1f69 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
The extended and eccentric E-DNA structure induced by cytosine methylation or bromination.
Vargason JM, Eichman BF, Ho PS
Nat Struct Biol 7 758-61 (2000)
PMID: 10966645

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113793 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*GP*GP*CP*GP*CP*C)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand NCO 1 x NCO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P4122
Unit cell:
a: 42.59Å b: 42.59Å c: 63.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.205 0.279
Expression system: Not provided

Quick links

Citations

6 review citations

Demethylation of (Cytosine-5-C-methyl) DNA and regulation of transcription in the epigenetic pathways of cancer development.
Patra et al. (2008)
5 more