› 1fcg

X-ray diffraction
2Å resolution

ECTODOMAIN OF HUMAN FC GAMMA RECEPTOR, FCGRIIA

Released:
DOI: 10.2210/pdb1fcg/pdb
PDB entry 1fcg coloured by chain, front view.
PDB entry 1fcg coloured by chain, side view.
PDB entry 1fcg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human leukocyte Fc receptor, Fc gammaRIIa.
Maxwell KF, Powell MS, Hulett MD, Barton PA, McKenzie IF, Garrett TP, Hogarth PM
Nat Struct Biol 6 437-42 (1999)
PMID: 10331870

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146139 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low affinity immunoglobulin gamma Fc region receptor II-a Chain: A
Molecule details ›
Chain: A
Length: 174 amino acids
Theoretical weight: 19.56 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P12318 (Residues: 34-207; Coverage: 61%)
Gene names: CD32, FCG2, FCGR2A, FCGR2A1, IGFR2
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MACSCIENCE M18X
Spacegroup: P21212
Unit cell:
a: 79.221Å b: 100.866Å c: 28.172Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.197 0.242
Expression system: Spodoptera frugiperda

Quick links

Citations

42 review citations

IgG Fc receptors.
Ravetch et al. (2001)
41 more

8 mentions without citation

Fc gamma receptors: glycobiology and therapeutic prospects.
Hayes et al. (2016)
7 more