› 1fd3

X-ray diffraction
1.35Å resolution

HUMAN BETA-DEFENSIN 2

Released:
DOI: 10.2210/pdb1fd3/pdb
PDB entry 1fd3 coloured by chain, front view.
PDB entry 1fd3 coloured by chain, side view.
PDB entry 1fd3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of human beta-defensin-2 shows evidence of higher order oligomerization.
Hoover DM, Rajashankar KR, Blumenthal R, Puri A, Oppenheim JJ, Chertov O, Lubkowski J
J Biol Chem 275 32911-8 (2000)
PMID: 10906336

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127396 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Defensin beta 4A Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 41 amino acids
Theoretical weight: 4.34 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O15263 (Residues: 24-64; Coverage: 100%)
Gene names: DEFB102, DEFB2, DEFB4, DEFB4A, DEFB4B
Sequence domains: Beta defensin
Structure domains: Antimicrobial Peptide, Beta-defensin 2; Chain A

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: P21212
Unit cell:
a: 50.05Å b: 103.91Å c: 28.27Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.161 0.164 0.237
Expression system: Not provided

Quick links

Citations

48 review citations

Defensins: antimicrobial peptides of innate immunity.
Ganz T. (2003)
47 more

35 mentions without citation

The antimicrobial peptides and their potential clinical applications.
Lei et al. (2019)
34 more