› 1fdg

X-ray diffraction
1.6Å resolution

BINDING OF A MACROCYCLIC BISACRIDINE AND AMETANTRONE TO CGTACG INVOLVES SIMILAR UNUSUAL INTERCALATION PLATFORMS (AMETANTRONE COMPLEX)

Released:
DOI: 10.2210/pdb1fdg/pdb
PDB entry 1fdg coloured by chain, front view.
PDB entry 1fdg coloured by chain, side view.
PDB entry 1fdg coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Binding of a macrocyclic bisacridine and ametantrone to CGTACG involves similar unusual intercalation platforms.
Yang XL, Robinson H, Gao YG, Wang AH
Biochemistry 39 10950-7 (2000)
PMID: 10998231

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113800 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*TP*AP*CP*G)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

3 bound ligands:
Ligand CO 2 x CO
Ligand 9TA 1 x 9TA
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C222
Unit cell:
a: 29.094Å b: 52.714Å c: 40.183Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.264 0.249 0.314
Expression system: Not provided

Quick links

Citations

2 review citations

Cations as hydrogen bond donors: a view of electrostatic interactions in DNA.
Subirana et al. (2003)
1 more

2 mentions without citation

DNA conformations and their sequence preferences.
Svozil et al. (2008)
1 more