› 1fec

X-ray diffraction
1.7Å resolution

UNLIGANDED CRITHIDIA FASCICULATA TRYPANOTHIONE REDUCTASE AT 1.7 ANGSTROM RESOLUTION

Released:
DOI: 10.2210/pdb1fec/pdb
PDB entry 1fec coloured by chain, front view.
PDB entry 1fec coloured by chain, side view.
PDB entry 1fec coloured by chain, top view.
Source organism: Crithidia fasciculata
Primary publication:
Crithidia Fasciculata Trypanothione Reductase at 1.70 A Resolution
Strickland CL, Karplus PA
To be published

Function and Biology Details

Reaction catalysed: 
Trypanothione + NADP(+) = trypanothione disulfide + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153807 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Trypanothione reductase Chains: A, B
Molecule details ›
Chains: A, B
Length: 490 amino acids
Theoretical weight: 53.18 KDa
Source organism: Crithidia fasciculata
Expression system: Escherichia coli
UniProt:
  • Canonical: P39040 (Residues: 2-491; Coverage: 100%)
Gene name: TPR
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand FAD 2 x FAD
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P21
Unit cell:
a: 57.8Å b: 160.7Å c: 60Å
α: 90° β: 99.4° γ: 90°
R-values:
R R work R free
0.204 0.204 0.256
Expression system: Escherichia coli

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