› 1fgn

X-ray diffraction
2.5Å resolution

MONOCLONAL MURINE ANTIBODY 5G9-ANTI-HUMAN TISSUE FACTOR

Released:
DOI: 10.2210/pdb1fgn/pdb
PDB entry 1fgn coloured by chain, front view.
PDB entry 1fgn coloured by chain, side view.
PDB entry 1fgn coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.G9 complex.
Huang M, Syed R, Stura EA, Stone MJ, Stefanko RS, Ruf W, Edgington TS, Wilson IA
J Mol Biol 275 873-94 (1998)
PMID: 9480775

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208556 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Immunoglobulin kappa constant Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.81 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P01837 (Residues: 1-107; Coverage: 100%)
Gene name: Igkc
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
IMMUNOGLOBULIN FAB 5G9 Chain: H
Molecule details ›
Chain: H
Length: 214 amino acids
Theoretical weight: 23.18 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELLIOTT GX-18
Spacegroup: P212121
Unit cell:
a: 91.6Å b: 93.7Å c: 60.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.217 0.304

Quick links

Citations

15 review citations

Folding funnels and binding mechanisms.
Ma et al. (1999)
14 more

14 mentions without citation

The ClusPro AbEMap web server for the prediction of antibody epitopes.
Desta et al. (2023)
13 more