› 1fgz

X-ray diffraction
2.05Å resolution

GRP1 PH DOMAIN (UNLIGANDED)

Released:
DOI: 10.2210/pdb1fgz/pdb
PDB entry 1fgz coloured by chain, front view.
PDB entry 1fgz coloured by chain, side view.
PDB entry 1fgz coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains.
Lietzke SE, Bose S, Cronin T, Klarlund J, Chawla A, Czech MP, Lambright DG
Mol Cell 6 385-94 (2000)
PMID: 10983985

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126701 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytohesin-3 Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 15.12 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: O08967 (Residues: 261-387; Coverage: 32%)
Gene names: Cyth3, Grp1, Pscd3
Sequence domains: PH domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
1 modified residue:
Ligand MSE 2 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P21212
Unit cell:
a: 40.7Å b: 107.6Å c: 37.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.223 0.277
Expression system: Escherichia coli

Quick links

Citations

41 review citations

The protein kinase B/Akt signalling pathway in human malignancy.
Nicholson et al. (2002)
40 more

3 mentions without citation

Molecular basis of phosphatidylinositol 4-phosphate and ARF1 GTPase recognition by the FAPP1 pleckstrin homology (PH) domain.
He et al. (2011)
2 more