Function and Biology Details
Reactions catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-|-Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly-|-Arg- and -Lys-|-Arg-.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero 240-mer (preferred)
PDBe Complex ID:
PDB-CPX-147207 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Foot and mouth disease virus VP1 capsid protein
Molecule details ›
Chain: 1
Length: 208 amino acids
Theoretical weight: 22.69 KDa
Source organism: Foot-and-mouth disease virus
Expression system: Mesocricetus auratus
UniProt:
Structure domains: Jelly Rolls
Length: 208 amino acids
Theoretical weight: 22.69 KDa
Source organism: Foot-and-mouth disease virus
Expression system: Mesocricetus auratus
UniProt:
- Canonical:
Q65095 (Residues: 1-208; Coverage: 100%)
Structure domains: Jelly Rolls
Capsid protein VP2
Molecule details ›
Chain: 2
Length: 218 amino acids
Theoretical weight: 24.3 KDa
Source organism: Foot-and-mouth disease virus
Expression system: Mesocricetus auratus
UniProt:
Structure domains: Jelly Rolls
Length: 218 amino acids
Theoretical weight: 24.3 KDa
Source organism: Foot-and-mouth disease virus
Expression system: Mesocricetus auratus
UniProt:
- Canonical: P15072 (Residues: 287-504; Coverage: 9%)
Structure domains: Jelly Rolls
Capsid protein VP3
Capsid protein VP4
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
wwPDB Validation report is not available for this entry.
Spacegroup:
I23
Expression system: Mesocricetus auratus
