› 1fpb

X-ray diffraction
2.6Å resolution

CRYSTAL STRUCTURE OF THE NEUTRAL FORM OF FRUCTOSE 1,6-BISPHOSPHATASE COMPLEXED WITH REGULATORY INHIBITOR FRUCTOSE 2,6-BISPHOSPHATE AT 2.6-ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb1fpb/pdb
PDB entry 1fpb coloured by chain, front view.
PDB entry 1fpb coloured by chain, side view.
PDB entry 1fpb coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
Crystal structure of the neutral form of fructose 1,6-bisphosphatase complexed with regulatory inhibitor fructose 2,6-bisphosphate at 2.6-A resolution.
Liang JY, Huang S, Zhang Y, Ke H, Lipscomb WN
Proc Natl Acad Sci U S A 89 2404-8 (1992)
PMID: 1312721

Function and Biology Details

Reaction catalysed: 
D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132778 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fructose-1,6-bisphosphatase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 335 amino acids
Theoretical weight: 36.5 KDa
Source organism: Sus scrofa
Expression system: Not provided
UniProt:
  • Canonical: P00636 (Residues: 2-336; Coverage: 99%)
Gene names: FBP, FBP1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand FDP 3 x FDP
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P3221
Unit cell:
a: 131.4Å b: 131.4Å c: 68.6Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.174 0.174 not available
Expression system: Not provided

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Citations

2 review citations

Recent and emerging anti-diabetes targets.
Mohler et al. (2009)
1 more