› 1ftl

X-ray diffraction
1.8Å resolution

CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH THE ANTAGONIST DNQX AT 1.8 A RESOLUTION

Released:
DOI: 10.2210/pdb1ftl/pdb
PDB entry 1ftl coloured by chain, front view.
PDB entry 1ftl coloured by chain, side view.
PDB entry 1ftl coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
Armstrong N, Gouaux E
Neuron 28 165-81 (2000)
PMID: 11086992

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 263 amino acids
Theoretical weight: 29.22 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-796; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand DNQ 2 x DNQ
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 62.153Å b: 93.703Å c: 97.369Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.245 0.219 0.272
Expression system: Escherichia coli

Quick links

Citations

98 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
97 more

16 mentions without citation

Emerging models of glutamate receptor ion channel structure and function.
Mayer ML. (2011)
15 more