› 1fw0

X-ray diffraction
1.9Å resolution

CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH KAINATE AT 2.0 A RESOLUTION

Released:
DOI: 10.2210/pdb1fw0/pdb
PDB entry 1fw0 coloured by chain, front view.
PDB entry 1fw0 coloured by chain, side view.
PDB entry 1fw0 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
Armstrong N, Gouaux E
Neuron 28 165-81 (2000)
PMID: 11086992

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148604 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 263 amino acids
Theoretical weight: 29.22 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-796; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand KAI 1 x KAI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21212
Unit cell:
a: 57.279Å b: 89.014Å c: 48.873Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.281 0.245 0.308
Expression system: Escherichia coli

Quick links

Citations

101 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
100 more

8 mentions without citation

Coevolutionary signals across protein lineages help capture multiple protein conformations.
Morcos et al. (2013)
7 more