› 1fwv

X-ray diffraction
2.2Å resolution

CRYSTAL STRUCTURE OF THE CYSTEINE-RICH DOMAIN OF MANNOSE RECEPTOR COMPLEXED WITH 3-SO4-LEWIS(A)

Released:
DOI: 10.2210/pdb1fwv/pdb
PDB entry 1fwv coloured by chain, front view.
PDB entry 1fwv coloured by chain, side view.
PDB entry 1fwv coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The molecular mechanism of sulfated carbohydrate recognition by the cysteine-rich domain of mannose receptor.
Liu Y, Misulovin Z, Bjorkman PJ
J Mol Biol 305 481-90 (2001)
PMID: 11152606

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178903 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Macrophage mannose receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 134 amino acids
Theoretical weight: 15.45 KDa
Source organism: Mus musculus
Expression system: Sus scrofa
UniProt:
  • Canonical: Q61830 (Residues: 21-154; Coverage: 9%)
Gene name: Mrc1
Sequence domains: Ricin-type beta-trefoil lectin domain
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

Carbohydrate polymer : NEW Components: MAG, SGA, FUC
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 39.608Å b: 41.158Å c: 99.646Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.208 0.23
Expression system: Sus scrofa

Quick links

Citations

4 review citations

Binding sugars: from natural lectins to synthetic receptors and engineered neolectins.
Arnaud et al. (2013)
3 more

3 mentions without citation

Variation in structural location and amino acid conservation of functional sites in protein domain families.
Pils et al. (2005)
2 more