› 1fxl

X-ray diffraction
1.8Å resolution

CRYSTAL STRUCTURE OF HUD AND AU-RICH ELEMENT OF THE C-FOS RNA

Released:
DOI: 10.2210/pdb1fxl/pdb
PDB entry 1fxl coloured by chain, front view.
PDB entry 1fxl coloured by chain, side view.
PDB entry 1fxl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for recognition of AU-rich element RNA by the HuD protein.
Wang X, Tanaka Hall TM
Nat Struct Biol 8 141-5 (2001)
PMID: 11175903

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150731 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
ELAV-like protein 4 Chain: A
Molecule details ›
Chain: A
Length: 167 amino acids
Theoretical weight: 18.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P26378 (Residues: 49-215; Coverage: 43%)
Gene names: ELAVL4, HUD, PNEM
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits
5'-R(P*UP*UP*UP*UP*AP*UP*UP*UP*U)-3' Chain: B
Molecule details ›
Chain: B
Length: 9 nucleotides
Theoretical weight: 2.73 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P21
Unit cell:
a: 30.31Å b: 99.38Å c: 33.34Å
α: 90° β: 106.4° γ: 90°
R-values:
R R work R free
0.193 0.192 0.239
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

28 review citations

RNA-binding proteins: modular design for efficient function.
Lunde et al. (2007)
27 more

27 mentions without citation

RNA sequence- and shape-dependent recognition by proteins in the ribonucleoprotein particle.
Stefl et al. (2005)
26 more