› 1g5y

X-ray diffraction
2Å resolution

THE 2.0 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE RXRALPHA LIGAND BINDING DOMAIN TETRAMER IN THE PRESENCE OF A NON-ACTIVATING RETINOIC ACID ISOMER.

Released:
DOI: 10.2210/pdb1g5y/pdb
PDB entry 1g5y coloured by chain, front view.
PDB entry 1g5y coloured by chain, side view.
PDB entry 1g5y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix.
Gampe RT, Montana VG, Lambert MH, Wisely GB, Milburn MV, Xu HE
Genes Dev 14 2229-41 (2000)
PMID: 10970886

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148730 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinoic acid receptor RXR-alpha Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 238 amino acids
Theoretical weight: 26.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19793 (Residues: 225-462; Coverage: 52%)
Gene names: NR2B1, RXRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand REA 2 x REA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 51.052Å b: 99.701Å c: 96.281Å
α: 90° β: 96.7° γ: 90°
R-values:
R R work R free
0.231 0.231 0.254
Expression system: Escherichia coli

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Citations

16 review citations

Peroxisome proliferator-activated receptor gamma and metabolic disease.
Willson et al. (2001)
15 more

16 mentions without citation

The retinoid X receptors and their ligands.
Dawson et al. (2012)
15 more