› 1g6o

X-ray diffraction
2.5Å resolution

CRYSTAL STRUCTURE OF THE HELICOBACTER PYLORI ATPASE, HP0525, IN COMPLEX WITH ADP

Released:
DOI: 10.2210/pdb1g6o/pdb
PDB entry 1g6o coloured by chain, front view.
PDB entry 1g6o coloured by chain, side view.
PDB entry 1g6o coloured by chain, top view.
Source organism: Helicobacter pylori
Primary publication:
Crystal structure of the hexameric traffic ATPase of the Helicobacter pylori type IV secretion system.
Yeo HJ, Savvides SN, Herr AB, Lanka E, Waksman G
Mol Cell 6 1461-72 (2000)
PMID: 11163218

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo hexamer (preferred)
homo dodecamer
Assembly name:
PDBe Complex ID:
PDB-CPX-181366 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bacterial type II secretion system protein E domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 330 amino acids
Theoretical weight: 37.91 KDa
Source organism: Helicobacter pylori
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7BK04 (Residues: 1-330; Coverage: 100%)
Gene names: ACM37_01770, C2R45_06065, C2R60_04995, C2R64_07520, C2R66_03525, C2R72_03110, C2S01_07015, C2S26_06255, CV728_03100, D8X81_02825, EC515_06990, EC547_07075, EC572_06310, EC594_00565, EDB76_02000, F7219_04320, F7220_05215, HP0525, SE88_02715, cag-alfa, cag-alpha, cagAlpha, cagalpha, virB11
Sequence domains: Type II/IV secretion system protein
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ADP 2 x ADP
Ligand PEG 5 x PEG
1 modified residue:
Ligand MSE 12 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P6322
Unit cell:
a: 112.62Å b: 112.62Å c: 234.83Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.224 0.224 0.289
Expression system: Escherichia coli

Quick links

Citations

56 review citations

Biogenesis, architecture, and function of bacterial type IV secretion systems.
Christie et al. (2005)
55 more

10 mentions without citation

Unveiling molecular scaffolds of the type IV secretion system.
Yeo et al. (2004)
9 more