› 1gac

Solution NMR

NMR structure of asymmetric homodimer of a82846b, a glycopeptide antibiotic, complexed with its cell wall pentapeptide fragment

Released:
DOI: 10.2210/pdb1gac/pdb
PDB entry 1gac coloured by chain, ensemble of 80 models, front view.
PDB entry 1gac coloured by chain, ensemble of 80 models, side view.
PDB entry 1gac coloured by chain, ensemble of 80 models, top view.
Source organism: Amycolatopsis orientalis
Primary publication:
Conformation of A82846B, a glycopeptide antibiotic, complexed with its cell wall fragment: an asymmetric homodimer determined using NMR spectroscopy.
Prowse WG, Kline AD, Skelton MA, Loncharich RJ
Biochemistry 34 9632-44 (1995)
PMID: 7626632

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162194 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
CELL WALL PENTAPEPTIDE Chains: A, B
Molecule details ›
Chains: A, B
Length: 5 amino acids
Theoretical weight: 490 Da
Source organism: Amycolatopsis orientalis
Expression system: Not provided
CHLOROORIENTICIN A Chains: C, D
Molecule details ›
Chains: C, D
Length: 7 amino acids
Theoretical weight: 1.15 KDa
Source organism: Amycolatopsis orientalis
Expression system: Not provided

Ligands and Environments

Carbohydrate polymer : NEW Components: RER, BGC
Carbohydrate polymer
1 bound ligand:
Ligand RER 2 x RER
4 modified residues:
Ligand FGA 2 x FGA
Ligand DAL 4 x DAL
Ligand GHP 4 x GHP
Ligand OMY 2 x OMY

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

5 review citations

Mechanism of action of oritavancin and related glycopeptide antibiotics.
Allen et al. (2003)
4 more

4 mentions without citation

The tale of SSB.
Bianco PR. (2017)
3 more