› 1gea

Solution NMR

RECEPTOR-BOUND CONFORMATION OF PACAP21

Released:
DOI: 10.2210/pdb1gea/pdb
PDB entry 1gea coloured by chain, ensemble of 25 models, front view.
PDB entry 1gea coloured by chain, ensemble of 25 models, side view.
PDB entry 1gea coloured by chain, ensemble of 25 models, top view.
Source organism: Homo sapiens
Primary publication:
Conformation of a peptide ligand bound to its G-protein coupled receptor.
Inooka H, Ohtaki T, Kitahara O, Ikegami T, Endo S, Kitada C, Ogi K, Onda H, Fujino M, Shirakawa M
Nat Struct Biol 8 161-5 (2001)
PMID: 11175907

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148391 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pituitary adenylate cyclase-activating polypeptide 27 Chain: A
Molecule details ›
Chain: A
Length: 21 amino acids
Theoretical weight: 2.52 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P18509 (Residues: 132-152; Coverage: 14%)
Gene name: ADCYAP1
Sequence domains: Peptide hormone

Ligands and Environments

No bound ligands
1 modified residue:
Ligand LYN 1 x LYN

Experiments and Validation Details

Entry percentile scores
Refinement method: Iterative relaxation matrix analysis (IRMA) and simulated annealing (SA)
Expression system: Not provided

Quick links

Citations

30 review citations

VPAC and PAC receptors: From ligands to function.
Dickson et al. (2009)
29 more

6 mentions without citation

Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS.
Sun et al. (2007)
5 more