› 1gjy

X-ray diffraction
2.2Å resolution

The X-ray structure of the Sorcin Calcium Binding Domain (SCBD) provides insight into the phosphorylation and calcium dependent processess

Released:
DOI: 10.2210/pdb1gjy/pdb
PDB entry 1gjy coloured by chain, front view.
PDB entry 1gjy coloured by chain, side view.
PDB entry 1gjy coloured by chain, top view.
Source organism: Cricetulus griseus
Primary publication:
The crystal structure of the sorcin calcium binding domain provides a model of Ca2+-dependent processes in the full-length protein.
Ilari A, Johnson KA, Nastopoulos V, Verzili D, Zamparelli C, Colotti G, Tsernoglou D, Chiancone E
J Mol Biol 317 447-58 (2002)
PMID: 11922676

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138336 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sorcin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 167 amino acids
Theoretical weight: 18.9 KDa
Source organism: Cricetulus griseus
UniProt:
  • Canonical: P05044 (Residues: 32-198; Coverage: 84%)
Gene name: SRI
Sequence domains:
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand SO4 5 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: C2
Unit cell:
a: 130.925Å b: 103.847Å c: 78.546Å
α: 90° β: 117.96° γ: 90°
R-values:
R R work R free
0.232 0.232 0.296

Quick links

Citations

5 review citations

Sorcin, a calcium binding protein involved in the multidrug resistance mechanisms in cancer cells.
Colotti et al. (2014)
4 more

1 mention without citation

Molecular modeling, molecular dynamics simulation, and essential dynamics analysis of grancalcin: An upregulated biomarker in experimental autoimmune encephalomyelitis mice.
Paul et al. (2022)