› 1gk5

Solution NMR

Solution Structure the mEGF/TGFalpha44-50 chimeric growth factor

Released:
DOI: 10.2210/pdb1gk5/pdb
PDB entry 1gk5 coloured by chain, ensemble of 10 models, front view.
PDB entry 1gk5 coloured by chain, ensemble of 10 models, side view.
PDB entry 1gk5 coloured by chain, ensemble of 10 models, top view.
Source organisms:
Primary publication:
Solution structure of the mEGF/TGFalpha44-50 chimeric growth factor.
Chamberlin SG, Brennan L, Puddicombe SM, Davies DE, Turner DL
Eur J Biochem 268 6247-55 (2001)
PMID: 11733021

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134049 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epidermal growth factor; Transforming growth factor alpha Chain: A
Molecule details ›
Chain: A
Length: 49 amino acids
Theoretical weight: 5.26 KDa
Source organisms: Expression system: Komagataella pastoris
UniProt:
  • Canonical: P01132 (Residues: 977-1018; Coverage: 4%)
  • Canonical: P01135 (Residues: 83-89; Coverage: 5%)
Gene names: Egf, TGFA
Sequence domains: EGF-like domain
Structure domains: Laminin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: TORSION ANGLE DYNAMICS WITH SIMULATED ANNEALING
Expression system: Komagataella pastoris

Quick links

Citations

1 review citation

Targeting tumor micro-environment for design and development of novel anti-angiogenic agents arresting tumor growth.
Gacche et al. (2013)
3 other articles