› 1gne

X-ray diffraction
2.5Å resolution

THE THREE-DIMENSIONAL STRUCTURE OF GLUTATHIONE S-TRANSFERASE OF SCHISTOSOMA JAPONICUM FUSED WITH A CONSERVED NEUTRALIZING EPITOPE ON GP41 OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1

Released:
DOI: 10.2210/pdb1gne/pdb
PDB entry 1gne coloured by chain, front view.
PDB entry 1gne coloured by chain, side view.
PDB entry 1gne coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Three-dimensional structure of Schistosoma japonicum glutathione S-transferase fused with a six-amino acid conserved neutralizing epitope of gp41 from HIV.
Lim K, Ho JX, Keeling K, Gilliland GL, Ji X, Rüker F, Carter DC
Protein Sci 3 2233-44 (1994)
PMID: 7538846

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140160 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase class-mu 26 kDa isozyme Chain: A
Molecule details ›
Chain: A
Length: 232 amino acids
Theoretical weight: 27.09 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: P08515 (Residues: 2-218; Coverage: 100%)
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand GSH 1 x GSH
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P43212
Unit cell:
a: 94.74Å b: 94.74Å c: 58.13Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.219 not available
Expression system: Not provided

Quick links

Citations

10 review citations

Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily.
Sheehan et al. (2001)
9 more

6 mentions without citation

α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.
Fauvet et al. (2012)
5 more