› 1god

X-ray diffraction
2.8Å resolution

MONOMERIC LYS-49 PHOSPHOLIPASE A2 HOMOLOGUE ISOLATED FROM THE VENOM OF CERROPHIDION (BOTHROPS) GODMANI

Released:
DOI: 10.2210/pdb1god/pdb
PDB entry 1god coloured by chain, front view.
PDB entry 1god coloured by chain, side view.
PDB entry 1god coloured by chain, top view.
Source organism: Cerrophidion godmani
Primary publication:
Crystal structure of myotoxin II, a monomeric Lys49-phospholipase A2 homologue isolated from the venom of Cerrophidion (Bothrops) godmani.
Arni RK, Fontes MR, Barberato C, Gutiérrez JM, Díaz C, Ward RJ
Arch Biochem Biophys 366 177-82 (1999)
PMID: 10356281

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160482 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Basic phospholipase A2 homolog GodMT-II Chain: A
Molecule details ›
Chain: A
Length: 121 amino acids
Theoretical weight: 13.73 KDa
Source organism: Cerrophidion godmani
UniProt:
  • Canonical: P81165 (Residues: 1-121; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P43212
Unit cell:
a: 60.56Å b: 60.56Å c: 84.72Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.188 0.282

Quick links

Citations

2 review citations

An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action.
Lomonte et al. (2003)
1 more

1 mention without citation

Structural and phylogenetic studies with MjTX-I reveal a multi-oligomeric toxin--a novel feature in Lys49-PLA2s protein class.
Salvador et al. (2013)