› 1gr2

X-ray diffraction
1.9Å resolution

STRUCTURE OF A GLUTAMATE RECEPTOR LIGAND BINDING CORE (GLUR2) COMPLEXED WITH KAINATE

Released:
DOI: 10.2210/pdb1gr2/pdb
PDB entry 1gr2 coloured by chain, front view.
PDB entry 1gr2 coloured by chain, side view.
PDB entry 1gr2 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure of a glutamate-receptor ligand-binding core in complex with kainate.
Armstrong N, Sun Y, Chen GQ, Gouaux E
Nature 395 913-7 (1998)
PMID: 9804426

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148604 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 279 amino acids
Theoretical weight: 30.74 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19491 (Residues: 400-796; Coverage: 32%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand KAI 1 x KAI
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 43.22Å b: 63.07Å c: 46.32Å
α: 90° β: 92.99° γ: 90°
R-values:
R R work R free
0.216 0.216 0.273
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

107 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
106 more

4 mentions without citation

Size matters in activation/inhibition of ligand-gated ion channels.
Du et al. (2012)
3 more