› 1gs4

X-ray diffraction
1.95Å resolution

Structural basis for the glucocorticoid response in a mutant human androgen receptor (ARccr) derived from an androgen-independent prostate cancer

Released:
DOI: 10.2210/pdb1gs4/pdb
PDB entry 1gs4 coloured by chain, front view.
PDB entry 1gs4 coloured by chain, side view.
PDB entry 1gs4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the glucocorticoid response in a mutant human androgen receptor (AR(ccr)) derived from an androgen-independent prostate cancer.
Matias PM, Carrondo MA, Coelho R, Thomaz M, Zhao XY, Wegg A, Crusius K, Egner U, Donner P
J Med Chem 45 1439-46 (2002)
PMID: 11906285

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145222 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Androgen receptor Chain: A
Molecule details ›
Chain: A
Length: 248 amino acids
Theoretical weight: 28.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10275 (Residues: 671-918; Coverage: 27%)
Gene names: AR, DHTR, NR3C4
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand ZK5 1 x ZK5
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P212121
Unit cell:
a: 56.35Å b: 66.23Å c: 73.05Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 not available 0.285
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

12 review citations

Chemistry and structural biology of androgen receptor.
Gao et al. (2005)
11 more

10 mentions without citation

Androgen receptor: structure, role in prostate cancer and drug discovery.
Tan et al. (2015)
9 more