› 1gsf

X-ray diffraction
2.7Å resolution

GLUTATHIONE TRANSFERASE A1-1 COMPLEXED WITH ETHACRYNIC ACID

Released:
DOI: 10.2210/pdb1gsf/pdb
PDB entry 1gsf coloured by chain, front view.
PDB entry 1gsf coloured by chain, side view.
PDB entry 1gsf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate.
Cameron AD, Sinning I, L'Hermite G, Olin B, Board PG, Mannervik B, Jones TA
Structure 3 717-27 (1995)
PMID: 8591048

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140083 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase A1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 221 amino acids
Theoretical weight: 25.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08263 (Residues: 2-222; Coverage: 100%)
Gene name: GSTA1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand EAA 4 x EAA
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 101.8Å b: 95.6Å c: 105.3Å
α: 90° β: 92.2° γ: 90°
R-values:
R R work R free
0.229 0.229 0.261
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Glutathione transferases: a structural perspective.
Oakley A. (2011)
10 more

4 mentions without citation

Halogen bonds in biological molecules.
Auffinger et al. (2004)
3 more