› 1gve

X-ray diffraction
1.38Å resolution

Aflatoxin aldehyde reductase (AKR7A1) from Rat Liver

Released:
DOI: 10.2210/pdb1gve/pdb
PDB entry 1gve coloured by chain, front view.
PDB entry 1gve coloured by chain, side view.
PDB entry 1gve coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
The crystal structure of rat liver AKR7A1. A dimeric member of the aldo-keto reductase superfamily.
Kozma E, Brown E, Ellis EM, Lapthorn AJ
J Biol Chem 277 16285-93 (2002)
PMID: 11839745

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153767 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aflatoxin B1 aldehyde reductase member 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 327 amino acids
Theoretical weight: 36.79 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P38918 (Residues: 1-327; Coverage: 100%)
Gene names: Afar, Akr7a1, Akr7a3
Sequence domains: Aldo/keto reductase family
Structure domains: NADP-dependent oxidoreductase domain

Ligands and Environments

3 bound ligands:
Ligand NAP 1 x NAP
Ligand GOL 12 x GOL
Ligand CIT 1 x CIT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7B
Spacegroup: C2
Unit cell:
a: 125.54Å b: 64.68Å c: 112.84Å
α: 90° β: 91.03° γ: 90°
R-values:
R R work R free
0.159 0.158 0.18
Expression system: Escherichia coli BL21

Quick links

Citations

7 review citations

The aldo-keto reductase superfamily and its role in drug metabolism and detoxification.
Barski et al. (2008)
6 more

1 mention without citation

Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action.
Lyagin et al. (2019)