› 1gvl

X-ray diffraction
1.8Å resolution

Human prokallikrein 6 (hK6)/ prozyme/ proprotease M/ proneurosin

Released:
DOI: 10.2210/pdb1gvl/pdb
PDB entry 1gvl coloured by chain, front view.
PDB entry 1gvl coloured by chain, side view.
PDB entry 1gvl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family.
Gomis-Rüth FX, Bayés A, Sotiropoulou G, Pampalakis G, Tsetsenis T, Villegas V, Avilés FX, Coll M
J Biol Chem 277 27273-81 (2002)
PMID: 12016211

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187789 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kallikrein-6 Chain: A
Molecule details ›
Chain: A
Length: 223 amino acids
Theoretical weight: 24.52 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q92876 (Residues: 21-243; Coverage: 98%)
Gene names: KLK6, PRSS18, PRSS9
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P212121
Unit cell:
a: 46Å b: 66.4Å c: 71.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.185 0.225
Expression system: Komagataella pastoris

Quick links

Citations

10 review citations

The emerging roles of human tissue kallikreins in cancer.
Borgoño et al. (2004)
9 more

6 mentions without citation

Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs).
Goettig et al. (2010)
5 more