› 1h0q

Solution NMR

NMR solution structure of a fully modified locked nucleic acid (LNA) hybridized to RNA

Released:
DOI: 10.2210/pdb1h0q/pdb
PDB entry 1h0q coloured by chain, ensemble of 20 models, front view.
PDB entry 1h0q coloured by chain, ensemble of 20 models, side view.
PDB entry 1h0q coloured by chain, ensemble of 20 models, top view.
Source organism: Synthetic construct
Primary publication:
NMR studies of fully modified locked nucleic acid (LNA) hybrids: solution structure of an LNA:RNA hybrid and characterization of an LNA:DNA hybrid.
Nielsen KE, Rasmussen J, Kumar R, Wengel J, Jacobsen JP, Petersen M
Bioconjug Chem 15 449-57 (2004)
PMID: 15149171

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196036 (preferred)
Entry contents:
2 distinct RNA molecules
Macromolecules (2 distinct):
5-D(*(LKC)P*(TLN)P*(LCG)P*(LCA)P*(TLN)P*(LCA)P* (TLN)P*(LCG)P*(LCC))-3 Chain: A
Molecule details ›
Chain: A
Length: 9 nucleotides
Theoretical weight: 2.93 KDa
Source organism: Synthetic construct
Expression system: Not provided
5-R(*GP*CP*AP*UP*AP*UP*CP*AP*G)-3 Chain: B
Molecule details ›
Chain: B
Length: 9 nucleotides
Theoretical weight: 2.86 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
3 modified residues:
Ligand TLN 3 x TLN
Ligand LCG 2 x LCG
Ligand LCA 2 x LCA

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

8 review citations

Locked nucleic acids: promising nucleic acid analogs for therapeutic applications.
Veedu et al. (2010)
7 more

6 mentions without citation

The structural diversity of artificial genetic polymers.
Anosova et al. (2016)
5 more