› 1h9f

Solution NMR

LEM DOMAIN OF HUMAN INNER NUCLEAR MEMBRANE PROTEIN LAP2

Released:
DOI: 10.2210/pdb1h9f/pdb
PDB entry 1h9f coloured by chain, ensemble of 10 models, front view.
PDB entry 1h9f coloured by chain, ensemble of 10 models, side view.
PDB entry 1h9f coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural characterization of the LEM motif common to three human inner nuclear membrane proteins.
Laguri C, Gilquin B, Wolff N, Romi-Lebrun R, Courchay K, Callebaut I, Worman HJ, Zinn-Justin S
Structure 9 503-11 (2001)
PMID: 11435115

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154500 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lamina-associated polypeptide 2, isoform alpha Chain: A
Molecule details ›
Chain: A
Length: 57 amino acids
Theoretical weight: 6.54 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P42166 (Residues: 103-159; Coverage: 8%)
Gene names: LAP2, TMPO
Sequence domains: LEM domain
Structure domains: Transcription Termination Factor Rho, Rna-binding Domain; Chain A, Domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

26 review citations

Life at the edge: the nuclear envelope and human disease.
Burke et al. (2002)
25 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)