› 1ha9

Solution NMR

SOLUTION STRUCTURE OF THE SQUASH TRYPSIN INHIBITOR MCoTI-II, NMR, 30 STRUCTURES.

Released:
DOI: 10.2210/pdb1ha9/pdb
PDB entry 1ha9 coloured by chain, ensemble of 30 models, front view.
PDB entry 1ha9 coloured by chain, ensemble of 30 models, side view.
PDB entry 1ha9 coloured by chain, ensemble of 30 models, top view.
Source organism: Momordica cochinchinensis
Primary publication:
Solution structure of the squash trypsin inhibitor MCoTI-II. A new family for cyclic knottins.
Heitz A, Hernandez JF, Gagnon J, Hong TT, Pham TT, Nguyen TM, Le-Nguyen D, Chiche L
Biochemistry 40 7973-83 (2001)
PMID: 11434766

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160631 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Trypsin inhibitor 2 Chain: A
Molecule details ›
Chain: A
Length: 34 amino acids
Theoretical weight: 3.48 KDa
Source organism: Momordica cochinchinensis
UniProt:
  • Canonical: P82409 (Residues: 1-34; Coverage: 100%)
Sequence domains: Squash family serine protease inhibitor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 72%
Refinement method: TORSION ANGLE MOLECULAR DYNAMICS

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Citations

30 review citations

Antimicrobial Peptides from Plants.
Tam et al. (2015)
29 more

15 mentions without citation

Beyond antibody engineering: directed evolution of alternative binding scaffolds and enzymes using yeast surface display.
Könning et al. (2018)
14 more