› 1hcl

X-ray diffraction
1.8Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150313 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 33.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 73.12Å b: 72.72Å c: 54.25Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.181 0.254
Expression system: Spodoptera frugiperda

Quick links

Citations

14 review citations

Regulation of protein kinases; controlling activity through activation segment conformation.
Nolen et al. (2004)
13 more

48 mentions without citation

Cyclin-dependent kinases.
Malumbres M. (2014)
47 more