› 1him

X-ray diffraction
2.9Å resolution

STRUCTURAL EVIDENCE FOR INDUCED FIT AS A MECHANISM FOR ANTIBODY-ANTIGEN RECOGNITION

Released:
DOI: 10.2210/pdb1him/pdb
PDB entry 1him coloured by chain, front view.
PDB entry 1him coloured by chain, side view.
PDB entry 1him coloured by chain, top view.
Source organisms:
Primary publication:
Structural evidence for induced fit as a mechanism for antibody-antigen recognition.
Rini JM, Schulze-Gahmen U, Wilson IA
Science 255 959-65 (1992)
PMID: 1546293

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-207916 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
IGG2A-KAPPA 17/9 FAB (LIGHT CHAIN) Chains: H, J
Molecule details ›
Chains: H, J
Length: 217 amino acids
Theoretical weight: 23.91 KDa
Source organism: Mus musculus
Expression system: Not provided
Structure domains: Immunoglobulins
IGG2A-KAPPA 17/9 FAB (HEAVY CHAIN) Chains: L, M
Molecule details ›
Chains: L, M
Length: 220 amino acids
Theoretical weight: 23.68 KDa
Source organism: Mus musculus
Expression system: Not provided
Structure domains: Immunoglobulins
Hemagglutinin Chain: P
Molecule details ›
Chain: P
Length: 9 amino acids
Theoretical weight: 927 Da
Source organism: Influenza A virus (A/reassortant/X-47(Victoria/3/1975 x Puerto Rico/8/1934)(H3N2))
Expression system: Not provided
UniProt:
  • Canonical: I6SHA6 (Residues: 117-124; Coverage: 1%)
Gene name: HA
Hemagglutinin Chain: R
Molecule details ›
Chain: R
Length: 10 amino acids
Theoretical weight: 1.04 KDa
Source organism: Influenza A virus (A/reassortant/X-47(Victoria/3/1975 x Puerto Rico/8/1934)(H3N2))
Expression system: Not provided
UniProt:
  • Canonical: I6SHA6 (Residues: 117-125; Coverage: 2%)
Gene name: HA

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P1
Unit cell:
a: 60.08Å b: 67.07Å c: 73.24Å
α: 89.9° β: 101.8° γ: 96.5°
R-values:
R R work R free
0.2 0.2 not available
Expression system: Not provided

Quick links

Citations

48 review citations

Anatomy of the antibody molecule.
Padlan EA. (1994)
47 more

6 mentions without citation

Normal-modes-based prediction of protein conformational changes guided by distance constraints.
Zheng et al. (2005)
5 more