› 1hk3

X-ray diffraction
2.8Å resolution

Human serum albumin mutant r218p complexed with thyroxine (3,3',5,5'-tetraiodo-l-thyronine)

Released:
DOI: 10.2210/pdb1hk3/pdb
PDB entry 1hk3 coloured by chain, front view.
PDB entry 1hk3 coloured by chain, side view.
PDB entry 1hk3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia.
Petitpas I, Petersen CE, Ha CE, Bhattacharya AA, Zunszain PA, Ghuman J, Bhagavan NV, Curry S
Proc Natl Acad Sci U S A 100 6440-5 (2003)
PMID: 12743361

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136176 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chain: A
Molecule details ›
Chain: A
Length: 585 amino acids
Theoretical weight: 66.51 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P02768 (Residues: 25-609; Coverage: 99%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

1 bound ligand:
Ligand T44 4 x T44
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P21
Unit cell:
a: 59.328Å b: 89.284Å c: 60.526Å
α: 90° β: 100.8° γ: 90°
R-values:
R R work R free
0.203 0.203 0.245
Expression system: Komagataella pastoris

Quick links

Citations

20 review citations

The extraordinary ligand binding properties of human serum albumin.
Fasano et al. (2005)
19 more

5 mentions without citation

Inherited defects of thyroxine-binding proteins.
Pappa et al. (2015)
4 more