› 1hql

X-ray diffraction
2.2Å resolution

The xenograft antigen in complex with the B4 isolectin of Griffonia simplicifolia lectin-1

Released:
DOI: 10.2210/pdb1hql/pdb
PDB entry 1hql coloured by chain, front view.
PDB entry 1hql coloured by chain, side view.
PDB entry 1hql coloured by chain, top view.
Source organism: Griffonia simplicifolia
Primary publication:
The xenograft antigen bound to Griffonia simplicifolia lectin 1-B(4). X-ray crystal structure of the complex and molecular dynamics characterization of the binding site.
Tempel W, Tschampel S, Woods RJ
J Biol Chem 277 6615-21 (2002)
PMID: 11714721

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186656 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Legume lectin domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 257 amino acids
Theoretical weight: 28.31 KDa
Source organism: Griffonia simplicifolia
UniProt:
  • Canonical: Q8W1R6 (Residues: 1-247; Coverage: 100%)
Sequence domains: Legume lectin domain
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: MBG, GLA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand MN 2 x MN
Ligand CA 2 x CA
1 modified residue:
Ligand PCA 2 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200, null
Spacegroup: P21212
Unit cell:
a: 111.21Å b: 51.28Å c: 77.11Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.233 0.254

Quick links

Citations

5 review citations

Computational modeling of the sugar-lectin interaction.
Neumann et al. (2004)
4 more

9 mentions without citation

Insights into the quaternary association of proteins through structure graphs: a case study of lectins.
Brinda et al. (2005)
8 more