› 1hqv

X-ray diffraction
2.3Å resolution

STRUCTURE OF APOPTOSIS-LINKED PROTEIN ALG-2

Released:
DOI: 10.2210/pdb1hqv/pdb
PDB entry 1hqv coloured by chain, front view.
PDB entry 1hqv coloured by chain, side view.
PDB entry 1hqv coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure of apoptosis-linked protein ALG-2: insights into Ca2+-induced changes in penta-EF-hand proteins.
Jia J, Tarabykina S, Hansen C, Berchtold M, Cygler M
Structure 9 267-75 (2001)
PMID: 11525164

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146324 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Programmed cell death protein 6 Chain: A
Molecule details ›
Chain: A
Length: 191 amino acids
Theoretical weight: 21.89 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P12815 (Residues: 1-191; Coverage: 100%)
Gene names: Alg2, Pdcd6
Sequence domains:
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: P4122
Unit cell:
a: 72.06Å b: 72.06Å c: 91.52Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.25 0.25 0.295
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Structural basis for diversity of the EF-hand calcium-binding proteins.
Grabarek Z. (2006)
5 more

3 mentions without citation

Ca2+ binding to EF hands 1 and 3 is essential for the interaction of apoptosis-linked gene-2 with Alix/AIP1 in ocular melanoma.
Subramanian et al. (2004)
2 more