› 1hvc

X-ray diffraction
1.8Å resolution

CRYSTAL STRUCTURE OF A TETHERED DIMER OF HIV-1 PROTEASE COMPLEXED WITH AN INHIBITOR

Released:
DOI: 10.2210/pdb1hvc/pdb
PDB entry 1hvc coloured by chain, front view.
PDB entry 1hvc coloured by chain, side view.
PDB entry 1hvc coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Crystal structure of a tethered dimer of HIV-1 proteinase complexed with an inhibitor.
Bhat TN, Baldwin ET, Liu B, Cheng YS, Erickson JW
Nat Struct Biol 1 552-6 (1994)
PMID: 7664084

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175770 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pol protein Chain: A
Molecule details ›
Chain: A
Length: 203 amino acids
Theoretical weight: 21.96 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: Q4VE97 (Residues: 1-123, 124-130; Coverage: 36%)
Gene name: pol
Sequence domains: Retroviral aspartyl protease
Structure domains: Acid Proteases

Ligands and Environments

1 bound ligand:
Ligand A79 1 x A79
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 52.1Å b: 59.8Å c: 62.2Å
α: 90° β: 90° γ: 90°
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Inhibitors of HIV-1 protease: a major success of structure-assisted drug design.
Wlodawer et al. (1998)
14 other articles

6 mentions without citation

DelPhi: a comprehensive suite for DelPhi software and associated resources.
Li et al. (2012)
5 more