› 1hzi

X-ray diffraction
2.05Å resolution

INTERLEUKIN-4 MUTANT E9A

Released:
DOI: 10.2210/pdb1hzi/pdb
PDB entry 1hzi coloured by chain, front view.
PDB entry 1hzi coloured by chain, side view.
PDB entry 1hzi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of interleukin 4 mutant E9A suggests polar steering in receptor-complex formation.
Hülsmeyer M, Scheufler C, Dreyer MK
Acta Crystallogr D Biol Crystallogr 57 1334-6 (2001)
PMID: 11526337

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138508 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-4 Chain: A
Molecule details ›
Chain: A
Length: 129 amino acids
Theoretical weight: 14.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05112 (Residues: 25-153; Coverage: 100%)
Gene name: IL4
Sequence domains: Interleukin 4
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

1 bound ligand:
Ligand SO4 5 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P41212
Unit cell:
a: 91.05Å b: 91.05Å c: 45.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.225 0.246
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Survey of the year 2001 commercial optical biosensor literature.
Rich et al. (2002)
1 more

3 mentions without citation

Denatured-state energy landscapes of a protein structural database reveal the energetic determinants of a framework model for folding.
Wang et al. (2008)
2 more