› 1i0u

Solution NMR

SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF A CONCATEMER OF EGF-HOMOLOGY MODULES OF THE HUMAN LOW DENSITY LIPOPROTEIN RECEPTOR

Released:
DOI: 10.2210/pdb1i0u/pdb
PDB entry 1i0u coloured by chain, front view.
PDB entry 1i0u coloured by chain, side view.
PDB entry 1i0u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
NMR structure and backbone dynamics of a concatemer of epidermal growth factor homology modules of the human low-density lipoprotein receptor.
Kurniawan ND, Aliabadizadeh K, Brereton IM, Kroon PA, Smith R
J Mol Biol 311 341-56 (2001)
PMID: 11478865

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134043 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low-density lipoprotein receptor Chain: A
Molecule details ›
Chain: A
Length: 82 amino acids
Theoretical weight: 9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01130 (Residues: 314-395; Coverage: 10%)
Gene name: LDLR
Structure domains: Laminin

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: 1. Torsion angles dynamics 2. Restrained molecular dynamics with calcium 3. Energy minimisation
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Structure and physiologic function of the low-density lipoprotein receptor.
Jeon et al. (2005)
6 more

1 mention without citation

In Silico Interactions of Natural and Synthetic Compounds with Key Proteins Involved in Alzheimer's Disease: Prospects for Designing New Therapeutics Compound.
Shah-Abadi et al. (2023)