› 1i7v

Solution NMR

THE SOLUTION STRUCTURE OF A BAY REGION 1R-BENZ[A]ANTHRACENE OXIDE ADDUCT AT THE N6 POSITION OF ADENINE OF AN OLIGODEOXYNUCLEOTIDE CONTAINING THE HUMAN N-RAS CODON 61 SEQUENCE

Released:
DOI: 10.2210/pdb1i7v/pdb
PDB entry 1i7v coloured by chain, front view.
PDB entry 1i7v coloured by chain, side view.
PDB entry 1i7v coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Intercalation of the (1R,2S,3R,4S)-N6-[1-(1,2,3,4-tetrahydro-2,3,4-trihydroxybenz[a]anthracenyl)]-2'-deoxyadenosyl adduct in the N-ras codon 61 sequence: DNA sequence effects.
Li Z, Tamura PJ, Wilkinson AS, Harris CM, Harris TM, Stone MP
Biochemistry 40 6743-55 (2001)
PMID: 11389588

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113947 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
5'-D(*CP*GP*GP*AP*CP*AP*(BZA)AP*GP*AP*AP*G)-3' Chain: A
Molecule details ›
Chain: A
Length: 11 nucleotides
Theoretical weight: 3.42 KDa
Source organism: Synthetic construct
Expression system: Not provided
5'-D(*CP*TP*TP*CP*TP*TP*GP*TP*CP*CP*G)-3' Chain: B
Molecule details ›
Chain: B
Length: 11 nucleotides
Theoretical weight: 3.29 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand BZA 1 x BZA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: NOE-restrained molecular dynamics/simulated annealing
Expression system: Not provided

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Citations

3 review citations

Biological properties of single chemical-DNA adducts: a twenty year perspective.
Delaney et al. (2008)
2 more