› 1iaz

X-ray diffraction
1.9Å resolution

EQUINATOXIN II

Released:
DOI: 10.2210/pdb1iaz/pdb
PDB entry 1iaz coloured by chain, front view.
PDB entry 1iaz coloured by chain, side view.
PDB entry 1iaz coloured by chain, top view.
Source organism: Actinia equina
Primary publication:
Crystal structure of the soluble form of equinatoxin II, a pore-forming toxin from the sea anemone Actinia equina.
Athanasiadis A, Anderluh G, Macek P, Turk D
Structure 9 341-6 (2001)
PMID: 11525171

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158433 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DELTA-actitoxin-Aeq1a Chains: A, B
Molecule details ›
Chains: A, B
Length: 179 amino acids
Theoretical weight: 19.85 KDa
Source organism: Actinia equina
Expression system: Escherichia coli
UniProt:
  • Canonical: P61914 (Residues: 36-214; Coverage: 92%)
Sequence domains: Sea anemone cytotoxic protein
Structure domains: Cytolysin/lectin

Ligands and Environments

1 bound ligand:
Ligand SO4 11 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P212121
Unit cell:
a: 81.62Å b: 129.04Å c: 31.76Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.185 0.235
Expression system: Escherichia coli

Quick links

Citations

26 review citations

Pore-forming toxins: ancient, but never really out of fashion.
Dal Peraro et al. (2016)
25 more

17 mentions without citation

Sea anemone (Cnidaria, Anthozoa, Actiniaria) toxins: an overview.
Frazão et al. (2012)
16 more