› 1ihc

X-ray diffraction
1.9Å resolution

X-ray Structure of Gephyrin N-terminal Domain

Released:
DOI: 10.2210/pdb1ihc/pdb
PDB entry 1ihc coloured by chain, front view.
PDB entry 1ihc coloured by chain, side view.
PDB entry 1ihc coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
X-ray crystal structure of the trimeric N-terminal domain of gephyrin.
Sola M, Kneussel M, Heck IS, Betz H, Weissenhorn W
J Biol Chem 276 25294-301 (2001)
PMID: 11325967

Function and Biology Details

Reactions catalysed: 
Adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP
ATP + molybdopterin = diphosphate + adenylyl-molybdopterin
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169918 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gephyrin Chain: A
Molecule details ›
Chain: A
Length: 188 amino acids
Theoretical weight: 20.52 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q03555 (Residues: 1-201; Coverage: 25%)
Gene names: Gph, Gphn
Sequence domains: Probable molybdopterin binding domain
Structure domains: MoaB/Mog-like domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: R3
Unit cell:
a: 65.769Å b: 65.769Å c: 114.396Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.199 0.203 0.219
Expression system: Escherichia coli

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Citations

15 review citations

GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
Luscher et al. (2011)
14 more

1 mention without citation

Gephyrin: a scaffold that builds a phase at the inhibitory postsynapses.
Hoffmann et al. (2021)