› 1ihh

X-ray diffraction
2.4Å resolution

2.4 ANGSTROM CRYSTAL STRUCTURE OF AN OXALIPLATIN 1,2-D(GPG) INTRASTRAND CROSS-LINK IN A DNA DODECAMER DUPLEX

Released:
DOI: 10.2210/pdb1ihh/pdb
PDB entry 1ihh coloured by chain, front view.
PDB entry 1ihh coloured by chain, side view.
PDB entry 1ihh coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
2.4 A crystal structure of an oxaliplatin 1,2-d(GpG) intrastrand cross-link in a DNA dodecamer duplex.
Spingler B, Whittington DA, Lippard SJ
Inorg Chem 40 5596-602 (2001)
PMID: 11599959

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113967 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
5'-D(*CP*CP*TP*CP*TP*GP*GP*TP*CP*TP*CP*C)-3' Chain: A
Molecule details ›
Chain: A
Length: 12 nucleotides
Theoretical weight: 3.57 KDa
Source organism: Synthetic construct
Expression system: Not provided
5'-D(*GP*GP*AP*GP*AP*CP*CP*AP*GP*AP*GP*G)-3' Chain: B
Molecule details ›
Chain: B
Length: 12 nucleotides
Theoretical weight: 3.76 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

3 bound ligands:
Ligand PT 1 x PT
Ligand DNH 1 x DNH
Ligand BA 1 x BA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1, APS BEAMLINE 19-ID
Spacegroup: I222
Unit cell:
a: 41.942Å b: 51.246Å c: 87.049Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.209 0.256
Expression system: Not provided

Quick links

Citations

17 review citations

The resurgence of platinum-based cancer chemotherapy.
Kelland L. (2007)
16 more

3 mentions without citation

Molecular dynamic simulations of cisplatin- and oxaliplatin-d(GG) intrastand cross-links reveal differences in their conformational dynamics.
Sharma et al. (2007)
2 more