› 1ijl

X-ray diffraction
2.6Å resolution

Crystal structure of acidic phospholipase A2 from deinagkistrodon acutus

Released:
DOI: 10.2210/pdb1ijl/pdb
PDB entry 1ijl coloured by chain, front view.
PDB entry 1ijl coloured by chain, side view.
PDB entry 1ijl coloured by chain, top view.
Source organism: Deinagkistrodon acutus
Primary publication:
Structure of an acidic phospholipase A2 from the venom of Deinagkistrodon acutus.
Gu L, Zhang H, Song S, Zhou Y, Lin Z
Acta Crystallogr D Biol Crystallogr 58 104-10 (2002)
PMID: 11752784

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181959 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acidic phospholipase A2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 123 amino acids
Theoretical weight: 14.09 KDa
Source organism: Deinagkistrodon acutus
UniProt:
  • Canonical: Q7SID6 (Residues: 1-123; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21
Unit cell:
a: 48.71Å b: 38Å c: 69.9Å
α: 90° β: 99.35° γ: 90°
R-values:
R R work R free
0.184 0.184 0.225

Quick links

Citations

2 review citations

Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis.
Kang et al. (2011)
1 more

1 mention without citation

Purification, crystallization and preliminary X-ray diffraction analysis of an acidic phospholipase A2 with vasoconstrictor activity from Agkistrodon halys pallas venom.
Zou et al. (2012)