› 1iju

X-ray diffraction
1.4Å resolution

HUMAN BETA-DEFENSIN-1

Released:
DOI: 10.2210/pdb1iju/pdb
PDB entry 1iju coloured by chain, front view.
PDB entry 1iju coloured by chain, side view.
PDB entry 1iju coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of human beta-defensin-1: new insights into structural properties of beta-defensins.
Hoover DM, Chertov O, Lubkowski J
J Biol Chem 276 39021-6 (2001)
PMID: 11486002

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-157949 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-defensin 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 36 amino acids
Theoretical weight: 3.94 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P60022 (Residues: 33-68; Coverage: 77%)
Gene names: BD1, DEFB1, HBD1
Sequence domains: Beta defensin

Ligands and Environments

2 bound ligands:
Ligand SO4 7 x SO4
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: P21
Unit cell:
a: 44.817Å b: 26.814Å c: 58.833Å
α: 90° β: 102.13° γ: 90°
R-values:
R R work R free
0.175 0.168 0.217
Expression system: Not provided

Quick links

Citations

28 review citations

Antimicrobial peptides: premises and promises.
Reddy et al. (2004)
27 more

10 mentions without citation

The antimicrobial peptides and their potential clinical applications.
Lei et al. (2019)
9 more