› 1ik7

X-ray diffraction
2.3Å resolution

Crystal Structure of the Uncomplexed Pelle Death Domain

Released:
DOI: 10.2210/pdb1ik7/pdb
PDB entry 1ik7 coloured by chain, front view.
PDB entry 1ik7 coloured by chain, side view.
PDB entry 1ik7 coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Cosolvent-induced transformation of a death domain tertiary structure.
Xiao T, Gardner KH, Sprang SR
Proc Natl Acad Sci U S A 99 11151-6 (2002)
PMID: 12177432

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170236 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase pelle Chains: A, B
Molecule details ›
Chains: A, B
Length: 108 amino acids
Theoretical weight: 12.45 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q05652 (Residues: 26-129; Coverage: 21%)
Gene names: CG5974, pll
Sequence domains: Death domain
Structure domains: Single helix bin

Ligands and Environments

2 bound ligands:
Ligand TRS 4 x TRS
Ligand MPD 1 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1, CHESS BEAMLINE F2
Spacegroup: I212121
Unit cell:
a: 70.106Å b: 95.542Å c: 103.196Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.268 0.239 0.258
Expression system: Escherichia coli BL21(DE3)

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Citations

2 review citations

Intracellular TLR signaling: a structural perspective on human disease.
Lasker et al. (2006)
1 more